Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells
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چکیده
منابع مشابه
Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells
Osteolytic bone disease is a common manifestation of multiple myeloma (MM) that leads to progressive skeleton destruction and is the most severe cause of morbidity in MM patients. It results from increased osteolytic activity and decrease osteoblastic function. Activation of mammalian chitinases chitotriosidase (CHIT1) and YKL40 is associated with osteoclast (OCs) differentiation and bone diges...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2015
ISSN: 1663-9812
DOI: 10.3389/fphar.2015.00226